Why Sermorelin Alone Isn’t Enough: The Synergistic Power of Pairing with a GHRP
In the world of peptide therapy, Sermorelin (a GHRH analog) is popular because it’s “natural” and FDA-approved in certain contexts. The harsh truth most clinics won’t tell you: using Sermorelin by itself is almost a complete waste of money and time. To get real, measurable growth hormone pulses you must combine it with a GHRP (Hexarelin, Ipamorelin, GHRP-6, etc.). The science proving this has been rock-solid for over 30 years.
The Landmark 1990 Study That Changed Everything
Source: Bowers et al., J Clin Endocrinol Metab 1990. Red line = GHRH + GHRP (AUC 10,065 μg·min/L). All other lines = <1,000.
- GHRH alone (green): modest peak, quickly shut down by somatostatin
- GHRP alone (blue): better, but still limited
- GHRH + GHRP (red): explosive synergistic release — up to 10× higher than either alone
Read the original 1990 Bowers paper →
Why Sermorelin (GHRH) Alone Fails in the Real World
- Somatostatin (the body’s natural GH brake) rapidly shuts down the signal from GHRH
- GHRPs simultaneously block somatostatin and directly stimulate GH release → perfect synergy
- Thousands of patients over the last three decades report little to no benefit from solo Sermorelin — but dramatic results once a GHRP is added
Modern Evidence (1990–2024) – The Synergy Still Holds
Real-World Benefits When You Get the Stack Right
- Men: Faster muscle gain, fat loss, workout recovery, libido, energy
- Women: Tighter skin, stronger hair/nails, better sleep, easier weight control
- Both: Deeper sleep, improved mood, and true anti-aging effects from restored youthful GH/IGF-1 levels
Your Next Step
At IncreaseMyT we only use evidence-based stacks — never solo Sermorelin. We combine pharmaceutical-grade Sermorelin with the most effective GHRPs (usually Hexarelin or Ipamorelin) and monitor your labs to keep you in the optimal range.
Always consult your physician before beginning any peptide protocol.
