What Is Hypogonadism and Why Is It a Cardiac Emergency?

Clinical hypogonadism = total testosterone consistently under 300 ng/dL + symptoms. Prevalence explodes after age 40 and reaches 20–30% by age 70. The downstream effects — visceral obesity, insulin resistance, chronic inflammation, dyslipidemia, and endothelial dysfunction — are the exact same pathways that cause heart attacks and strokes.

The Major Studies – In Detail

• • 2019 Meta-analysis of 37 studies – 42,000+ men
    Researchers from the UK and Australia pooled data from four continents and found men in the lowest quartile of testosterone had a 17% higher risk of cardiovascular events and a 54% higher risk of cardiovascular death compared to men in the highest quartile — even after adjusting for age, BMI, diabetes, and blood pressure.
    Read the full meta-analysis here
  • Circulation: Heart Failure – 2016 review on low T and chronic HF
    In men already diagnosed with heart failure, those with low testosterone had significantly worse exercise capacity, higher inflammatory markers (CRP, IL-6), and double the rate of major adverse cardiac events over 3 years. The authors concluded low T is both a marker and a maker of worse HF prognosis.
    Full paper – Circulation: Heart Failure
  • Diabetes Care 2016 – Testosterone and incident type 2 diabetes
    Longitudinal study of 1,800 community-dwelling men showed that men with total testosterone < 300 ng/dL had a 42% increased risk of developing diabetes over 5–10 years, independent of obesity. Restoring testosterone reverses insulin resistance in most men within months.
    Diabetes Care – Testosterone & Diabetes Risk
  • JAMA Internal Medicine – Low T and all-cause mortality
    Large U.S. cohort followed for 10+ years. Men with total testosterone in the bottom third had a 38% higher all-cause mortality rate and a 51% higher cardiovascular mortality rate than men in the top third — again, after controlling for every traditional risk factor.
    JAMA Internal Medicine – Full Study

The Good News: Modern TRT Is Heart-Protective

The 2023 TRAVERSE cardiovascular outcomes trial (5,246 men with preexisting CVD or high risk) proved once and for all that physiological-dose TRT does not increase major adverse cardiac events — and may actually lower them in the right patients.

Long-term European registries (Germany, UK) following men for 8–12 years show men on sustained TRT have significantly fewer heart attacks, strokes, and cardiac deaths than untreated hypogonadal controls.

Don’t Gamble With a Fixable Risk Factor

If your total testosterone is low and you have symptoms, you are carrying one of the strongest cardiovascular risk factors known to medicine — and it’s 100% treatable.

At IncreaseMyT we restore men to 900–1200+ ng/dL with physician-monitored injectable or ultra-potent topical protocols, full lab follow-up, and optional HCG to keep everything functioning optimally. No $99 shortcuts, no missing pieces — just real, evidence-based medicine.

Protect your heart. Reclaim your life.

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