The Natty Stack: Optimizing Natural Testosterone, Sperm Motility, Mitochondrial Health, and Fertility
The Natty Stack is a targeted, evidence-informed protocol designed for men who want to enhance vitality, fertility, and cellular energy using natural stimulation rather than heavy exogenous hormone replacement. This stack combines Human Chorionic Gonadotropin (HCG), glutathione, NAD+ nasal spray, and microdosed tirzepatide to support endogenous testosterone production, sperm quality, mitochondrial function, and reproductive hormones—often with benefits independent of weight loss.
What is the Natty Stack?
The Natty Stack (short for “natural stack”) is a synergistic combination focused on stimulating your body’s own systems rather than replacing them. Key components include:
- HCG – Mimics LH to stimulate natural testicular testosterone production
- Glutathione – Master antioxidant that improves sperm motility, supports detoxification, and promotes glowing skin
- NAD+ Nasal Spray – Boosts mitochondrial function for better cellular energy and recovery
- Microdosed Tirzepatide – Dual GLP-1/GIP agonist that enhances fertility and sex hormones (testosterone, LH, FSH, SHBG) independent of weight loss
This protocol is ideal for men dealing with age-related decline, fertility concerns, low energy, or metabolic challenges.
Benefits of HCG in the Natty Stack
HCG binds to LH receptors in the testes, promoting Leydig cell activity and increasing intratesticular testosterone. Low-dose HCG monotherapy has been shown to raise serum testosterone effectively while preserving natural production pathways. It also helps prevent testicular atrophy and supports sperm production—making it especially useful for fertility-focused protocols.
To learn more about HCG in hormone optimization, read our guide: HCG for TRT: Prevent Atrophy & Preserve Fertility.
Glutathione: Beyond Sperm Motility
Glutathione (GSH) is the body’s master antioxidant. It significantly reduces oxidative stress—a primary cause of poor sperm quality—improving motility and protecting testicular structure. Beyond reproduction, it delivers powerful benefits:
- Skin health: Reduces melanin, wrinkles, and UV spots while improving elasticity for a brighter, youthful glow
- Detoxification: Supports liver function, reduces cell damage in fatty liver conditions, and improves insulin sensitivity
- Immune & anti-aging: Modulates inflammation, corrects deficiencies, and supports cognition, strength, and physical function in aging adults
Explore more in our article: Injectable Glutathione: Benefits, Skin Glow & Detox.
NAD+ Nasal Spray for Mitochondrial Optimization
NAD+ is critical for mitochondrial energy production and cellular repair. Declining levels contribute to fatigue and metabolic slowdown with age. Nasal delivery provides efficient absorption, and supplementation has been shown to reduce mitochondrial damage, lower inflammation, and improve cognitive and metabolic health via pathways like SIRT1/PGC-1α.
Learn how NAD+ fits into longevity programs: 90-Day Sermorelin/GHRP-2 Troche + NAD+ Nasal Spray Vitality Program.
Tirzepatide: Fertility & Hormone Benefits Beyond Weight Loss
Tirzepatide is a dual GLP-1/GIP receptor agonist best known for metabolic effects, but emerging evidence shows it directly improves fertility and sex hormones—often independent of weight loss. In men, it raises testosterone, LH, FSH, and SHBG while lowering estradiol and improving erectile function and sperm parameters. In women, it restores ovulation, reduces androgens in PCOS, and enhances reproductive health through improved insulin sensitivity and hormonal balance.
We use microdosing (starting low, e.g., 1.5 - 3 mg weekly) to capture these benefits with minimal side effects.
Read more: Tirzepatide Improves Testosterone, Fertility & Hormones in Men & Women.
Implementation & Dosing – Minimal & Personalized
This program requires only 2 small water-based subcutaneous (subQ) shots per week, making it highly convenient.
Typical starting protocol (customized):
- HCG: 250–500 IU subQ twice weekly
- Glutathione: 200–600 mg oral daily (injection optional)
- NAD+ Nasal Spray: 100–300 mg daily
- Tirzepatide: Microdose 2.5–5 mg subQ once weekly (often combined with one HCG shot to maintain only 2 injections total)
Your Next Step
At IncreaseMyT, every protocol is doctor-prescribed and lab-monitored to ensure safe, effective optimization tailored to you. We focus on evidence-based approaches that support your body’s natural systems for long-term vitality.
External References & Supporting Studies
- Human Chorionic Gonadotropin monotherapy for hypogonadal symptoms
- Dose-dependent increase in intratesticular testosterone with low-dose HCG
- Glutathione improves sperm quality in diabetic models
- Glutathione antiaging and antimelanogenic effects
- Topical oxidized glutathione improves skin condition
- NAD+ ameliorates mitochondrial damage and cognition
- NAD+ metabolism in aging and disease
- Tirzepatide improves metabolic hypogonadism and erectile function
- GLP-1 agonists and human fertility
- Tirzepatide utility in PCOS management
